Learning From Glycosuria: FIG. 1.

Learning From Glycosuria

Plasma glucose is filtered freely through the glomerular barrier. In a 70-kg adult with a glomerular filtration rate of 120 mL $ min per 1.73 m and an average, around-the-clock plasma glucose concentration of 120 mg/dL (6.7 mmol/L), ;200 g of glucose are transferred daily from the bloodstream into the preurine. If nothing else happened, the whole-body mass of free glucose (some 20 g in a distri...

Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696

In the March issue of Diabetes, there is a very interesting article by Jurczak et al. (1) about glucose homeostasis and b-cell function in mice with a deletion in SGLT-2. There is also an accompanying editorial by Ferrannini (2) that is appropriately laudatory to the article but there are some extraordinary comments including, “Collectively, these findings prove that reduced SGLT-2 activity—whe...

Fig. 1

Response to Comment on: Ferrannini. Learning From Glycosuria. Diabetes 2011;60:695–696

The comment that Dr. Stanton found extraordinary reads as follows: “Collectively, these findings prove that reduced SGLT-2 activity—whether genetically or experimentally induced—is efficacious and relatively safe..” (1). This sentence referred to the animal studies described in the preceding paragraph, as becomes even more apparent in the following sentence that reads: “The development of SGLT-...

Fig. 1: Mpeg-4 Coding Scheme

A programmable processor architecture for MPEG-4 video is proposed, that can serve as a coprocessor module in MPEG-4 decoder systems. It consists of a 64-bit dual-issue VLIW macroblock engine, a separate RISC core for bitstream parsing and system processing, and an autonomous I/O processor. A separate DSP is used for MPEG audio support. The architecture is fully programmable and supports parall...